'Usual suspect' brainlesions appear not to cause most severe disability in MSpatients
The results were reported in a poster session on Feb. 23 at the annual meeting of the Americas Committee for Treatment and Research of Multiple Sclerosis in San Diego.
The individuals in the severely disabled cohort are residents of The Boston Home in Dorchester, Massachusetts, a specialized residential facility for individuals with advanced progressive neurological disorders including MS. The question of what distinguishes people with severe MS from those who respond well to therapies and continue to live nearly normal lives for decades after diagnosis has confounded patients, caregivers and clinicians for too long, said Zivadinov.
While lesion load in both groups was not materially different, the study revealed other important distinctions between the groups in brain scans and cognitive tests. Severely affected people exhibited lower efficiency in thalamic structural connectivity, meaning they demonstrated lower structural connectivity of the associated brain networks than their less-disabled counterparts.
"You could see the wheels turning as soon as Dr. Zivadinov and his team met the residents of The Boston Home," recalled Montani."Dr. Zivadinov's focus on the patient is what made this possible. His patient-centered approach leads to research that is highly relevant, validated and pursued with an urgency to find answers that offer hope.
Belgique Dernières Nouvelles, Belgique Actualités
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