'POEMS syndrome' refers to polyneuropathy, organomegaly, endocrinopathy/edema, monoclonal gammopathy, and skin changes.
PolyneuropathyPathophysiology Taken together, these symptoms reflect a paraneoplastic disease that, in rare cases, arises in patients with plasma cell neoplasms.What is POEMS syndrome? A plasma cell neoplasia is a benign or malignant disease defined by the overproduction of plasma cells. The three types of plasma cell neoplasms include monoclonal gammopathy of undetermined significance , plasmacytoma, and multiple myeloma.
Polyneuropathy Polyneuropathy can cause patients with POEMS syndrome to experience numbness, tingling, and/or weakness in their extremities, particularly in the legs and hands. Patients may also feel burning, tickling, numbness, and/or prickling sensations in the skin.Organomegaly POEMS syndrome often leads to spleen, liver, and/or lymph node enlargement.
Monoclonal gammopathy Monoclonal gammopathy is the presence of excessive monoclonal proteins in the blood due to the circulation of abnormal plasma cells. Other symptoms In addition to the hallmark symptoms of POEMS syndrome, several other systemic manifestations of this disorder have been described.
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