What is the association between air ventilation and pathogen transmission? AIrVentilation Ventilation Pathogen Transmission medrxivpreprint KU_Leuven
By Bhavana KunkalikarSep 27 2022Reviewed by Aimee Molineux In a recent study posted to the medRxiv* preprint server, researchers assessed the association between indoor air respiratory pathogens and natural ventilation, carbon dioxide levels, and air filtration.
Between October 2021 and April 2022, the team collected 341 ambient air samples at 21 sampling locations. By treating the quantitative polymerase chain reaction results of each pathogen in a sample as a single observation, the team examined the independent impacts of a variety of variables on airborne pathogen detection and concentration. The generated models had within-sample correlation adjustments and included pathogen type as a covariate.
In the nursery environment depicted, human bocavirus, human enterovirus, human cytomegalovirus, and Streptococcus pneumoniae were nearly always positive. Over the winter, the team noticed a long rise in human adenovirus and Pneumocystis jirovecii infections.
The qPCR Ct value declined by 0.13 for each 100 ppm rise in CO2. In contrast to the earlier analyses, natural ventilation was not substantially linked to concentration. However, there was a 0.57 increase in average Ct when air filtering was present, which was substantially linked with pathogen concentration. Also, performing an MLRM and when removing imputed values, significance levels and effect sizes were comparable.
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