What is the association between farnesoid X receptor inhibition and protection against COVID-19? natureportfolio SCICambridge COVID19 SARSCoV2 Protection FarnesoidXReceptor
By Bhavana KunkalikarDec 9 2022Reviewed by Aimee Molineux In a recent study published in Nature, researchers assessed the association between farnesoid X receptor inhibition and severe acute respiratory syndrome coronavirus 2 infection.
About the study In the present study, researchers identified the FXR as a direct regulator of angiotensin-converting enzyme-2 transcription among respiratory and gastrointestinal tissues impacted by COVID-19. Related StoriesTo test whether ACE2 regulation is the sole mechanism through which ZGG and UDCA inhibit SARS-CoV-2 infection, HEK293T cells were modified to over-express ACE2 irrespective of FXR with ZGG or UDCA followed by SARS-CoV-2 infection. The potential effects of UDCA treatment on COVID-19 patient outcomes were also tested by querying the COVID-Hep/SECURELiver registries.
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