What is the prevalence of contraindications to Paxlovid among hospitalized COVID-19 patients? univ_paris_cite COVID19 SARSCoV2 Paxlovid Coronavirus
By Neha MathurNov 17 2022Reviewed by Aimee Molineux In a recent study published in JAMA Network Open, researchers examined the prevalence of contraindications to nirmatrelvir-ritonavir in hospitalized coronavirus disease 2019 patients.
However, in certain circumstances, Paxlovid should be avoided due to the effects of ritonavir. In some patients, ritonavir elevates the concentrations of drugs more dependent on cytochrome P450, family 3, and subfamily A metabolism, for instance, in patients with severe kidney and liver impairments.
The primary study outcome was the number of patients with contraindications to nirmatrelvir-ritonavir. Next, the researchers determined the proportion of individuals who died within 28 days of hospitalization. These patients might have needed another therapy in the ambulatory setting. Study findings Only 62,525 COVID-19 inpatients met the study criteria, of which 9136 had a medical contraindication to nirmatrelvir-ritonavir. The study population comprised 31,561 women [50.5%], and the mean age of the participants was 52.8 years. The researchers noted that medical contraindication rates to nirmatrelvir-ritonavir were higher in men than women .
Belgique Dernières Nouvelles, Belgique Actualités
Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.
Covid victims' families target Matt Hancock by flying 'get out of here' banner over jungle campITV declined to comment on the protest - or on allegations that production staff had contacted the authorities to attempt to file a complaint
Lire la suite »
Matt Hancock: Covid campaigners fly banner over I'm A Celebrity jungleCovid family groups fly a message for the former health secretary over the I'm A Celebrity camp.
Lire la suite »
'Ooh la la!' France is mired in 'laziness epidemic', study showsA survey has suggested French people have become lazier than they were before the Covid pandemic.
Lire la suite »
China's zero-COVID rules spark violent protests in GuangzhouSince the beginning of the week more than 5,000 new COVID cases have been reported in the city of Guangzhou, both symptomatic and asymptomatic. Restrictions have sparked protests in the street
Lire la suite »
Take that, covid! “Revenge” tourism takes offPeople who were stuck at home during the pandemic are filling up beaches and sun-loungers once again
Lire la suite »