Researchers identify differences in spontaneous brain activity in people with Downsyndrome UniBarcelona SciReports
. Other differences could be due to the already demonstrated amyloid deposition that takes place within the ages of our sample in cognitive stable DS. Some of the results found are also linked with the structural abnormalities already found in this population in the frontal, temporal, parietal and cerebellar lobes. Moreover, abnormalities have also been found in the DMN, a network that has already been demonstrated to be disrupted in DS.
Finally, as both techniques used in this study are data-driven, it is not necessary to have a prior hypothesis of the seed regions in the analysisMRI, both techniques are valuable tools for studying this population without knowing the specific underlying pathology. Both techniques have localized brain areas that are different in both populations.
The correlations and regression analysis performed in this study demonstrate that differences in both groups depend highly on their cognitive profile, and the level of prediction for the cognitive evaluation is high. This study is not exempt from some limitations. In this sense, the difficulties in recruiting samples in this particular population and, of course, the high degree of movement during scanning in the DS population limited the study's sample size. However, it is important to highlight that this study’s sample size is in accordance with the typical sample size used in neuroimaging.
There are also some strengths of the study that are worth mentioning. To our knowledge, this is the first study to explore regional spontaneous brain activity in a population with DS compared to controls. Moreover, the high control of the age of the study is valuable because of the early onset of AD in this population. This study allows us to affirm that the differences found between the two populations are not because of the clinical symptomatology of AD.
Belgique Dernières Nouvelles, Belgique Actualités
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