Viral genes passed down by our ancestors can be 'woken up' when a person has cancer and join the fight against the tumour.
Viruses that have spent millions of years hiding in human DNA help the body fight cancer, scientists say.- the leading cause of cancer-related deaths worldwide - to understand why some patients respond better to immunotherapy than others.
They found viral genes passed down by our ancestors can be"woken up" when a person has cancer and join the fight against the tumour.How cancer vaccines work The research team looked at why patients with antibody-producing B cells around their tumour tended to respond better to immunotherapy. They found these B cells boost the immune response to cancer because they produce antibodies that bind to the tumour.The key to this response is hidden in ancient viral DNA, called endogenous retroviruses .This viral DNA has been passed down from the historic infections of our ancestors and makes up about 5% of human DNA.The fragments of viruses are enough to trigger an immune response. The body thinks the tumour cells are infected and so attacks them.
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