A Review published in Translational Neurodegeneration discusses how physical exercise improves crucial molecular pathways and biological processes associated with metabolic disorders in Alzheimer’s disease.
]. Many of the results on the effects of exercise on AD metabolism as discussed in this paper are mainly based on studies obtained in animal models. However, the study duration and the sample size, which are less limiting in animal studies than in human trials, often lead to discrepancies in results; therefore, further large-scale clinical trials in AD patients are still urgently needed.
AD pathophysiology is multifaceted and involves a combination of genomic, metabolomic, interactomic and environmental factors. Future translational research on cellular/molecular metabolism and brain health should be actively applied to systems biology to elucidate intercellular and subcellular metabolic pathways, and ultimately reveal brain cell metabolic molecular signatures of AD.
Belgique Dernières Nouvelles, Belgique Actualités
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