Charting a Path Forward: Assessing the Science of Chemical Risk Evaluations under the Toxic Substances Control Act in the Context of Recent National Academies Recommendations | Environmental Health Perspectives | Vol. 130, No. 2

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Charting a Path Forward: Assessing the Science of Chemical Risk Evaluations under the Toxic Substances Control Act in the Context of Recent National Academies Recommendations | Environmental Health Perspectives | Vol. 130, No. 2
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Study: EPA approach to assessing chemical health risks falls short johnshopkins

In its risk evaluation of 1,4-D, the U.S. EPA stated: “EPA has exercised its authority in TSCA Section 6 to exclude from the scope of this risk evaluation conditions of use associated with 1,4-D generated as a by-product in manufacturing, industrial and commercial uses” . As a result, the U.S.

The U.S. EPA’s SACC criticized this approach, stating that the U.S. EPA had not provided an adequate scientific basis for this policy decision . A basic principle of chemical risk assessment is that risk is informed by the total extent of exposure to a substance. Such exclusions underestimate the totality of chemical exposure, thereby leading to lower estimates of risk.

Members noted that the statement ‘risk could be underestimated’ because legacy exposures were not included is an understatement. Almost all the existing sources of exposure come from ‘legacy exposure’; the so called ‘bystander exposure’ is limited in scope and much focused, and as such it is not generalizable. An important feature is that legacy exposures could impact some exposures more than others and thus differentially impact the risk estimates.

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