Smartphone study reveals that bodily rhythm affects behavior unileidennews NaturePortfolio
. Finally, our method extracted circa periods which may contain a complex mixture of specific periods, leaving open the possibility of synchronized rhythms remaining confined to highly specific periods.
The menstrual cycles do not easily explain the biased expression of the ~25-day behavioral rhythm in females. After all, many of the males expressed the same rhythm, and the meta rhythm was found across the adult lifespan. In general, the resilience of multi-day rhythms even in advanced age indicates the role of fundamental underlying processes that do not succumb to the broad age-related behavioral, cognitive, and lifestyle changes.
There are some notable limitations of our study. First, this study was not designed to reveal the mechanisms underlying the multi-day rhythms and was tuned to address whether they existed at all in day-to-day behavior. For instance, the ~7 day behavioral rhythms found here may be driven by intrinsic biological process or social factors. Still, by leveraging the inter-individual differences we offer some indications on the role of age, gender, and common environmental factors.
Non-negative matrix factorization enabled us to interpret an otherwise complex expression of multi-day rhythms spanning diverse behaviors in healthy individuals and provides strong evidence for rhythmic real behavioral outputs that have long escaped scientific explorations. The behaviors in which these rhythms were expressed varied from person to person, and from one rhythm to the next.
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Increased iron deposition in nucleus accumbens associated with disease progression and chronicity in migraine - BMC MedicineBackground Migraine is one of the world’s most prevalent and disabling diseases. Despite huge advances in neuroimaging research, more valuable neuroimaging markers are still urgently needed to provide important insights into the brain mechanisms that underlie migraine symptoms. We therefore aim to investigate the regional iron deposition in subcortical nuclei of migraineurs as compared to controls and its association with migraine-related pathophysiological assessments. Methods A total of 200 migraineurs (56 chronic migraine [CM], 144 episodic migraine [EM]) and 41 matched controls were recruited. All subjects underwent MRI and clinical variables including frequency/duration of migraine, intensity of migraine, 6-item Headache Impact Test (HIT-6), Migraine Disability Assessment (MIDAS), and Pittsburgh Sleep Quality Index (PSQI) were recorded. Quantitative susceptibility mapping was employed to quantify the regional iron content in subcortical regions. Associations between clinical variables and regional iron deposition were studied as well. Results Increased iron deposition in the putamen, caudate, and nucleus accumbens (NAC) was observed in migraineurs more than controls. Meanwhile, patients with CM had a significantly higher volume of iron deposits compared to EM in multiple subcortical nuclei, especially in NAC. Volume of iron in NAC can be used to distinguish patients with CM from EM with a sensitivity of 85.45% and specificity of 71.53%. As the most valuable neuroimaging markers in all of the subcortical nuclei, higher iron deposition in NAC was significantly associated with disease progression, and higher HIT-6, MIDAS, and PSQI. Conclusions These findings provide evidence that iron deposition in NAC may be a biomarker for migraine chronicity and migraine-related dysfunctions, thus may help to understand the underlying vascular and neural mechanisms of migraine. Trial registration ClinicalTrials.gov, number NCT04939922.
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The Human Genome Project transformed biologyGenomics will increasingly inform doctors’ decisions. Starting later this year, 100,000 babies in England will have their genomes sequenced and screened for around 200 conditions
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New fashion trend spotted at Aintree racecourse this ThursdayThere's a common trend this year and we're loving it
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Capcom is teasing ‘big news’ for a Street Fighter 6 showcase next week | VGCCapcom has announced a Street Fighter 6 showcase for next week, and it's teasing “big news” for the 30-minute digital event, which will be hosted by rapper Lil Wayne
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