A brand-new kind of drug, tested in mice, shows promising new results that could lead to the development of a new weight-loss drug that mimics exercise.
The new drug targets a group of proteins in the body known as ERRs, which are responsible for activating some of the most important metabolic pathways in energy-gobbling tissues like muscles, the heart, and the brain. The ERRs are more active when people exercise, but they have proven difficult to activate with drugs., the researchers reported that they had successfully designed SLU-PP-332 to boost activity of the ERRs.
Other exercise mimetics have been tested, but none have made it to market, in part because it takes years to develop a new drug. Specifically targeting obesity with a drug has historically been difficult because of how complex obesity is. That was until Ozempic, Wegovy, and Mounjaro, developed to treat diabetes, also caused people to lose weight.
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