Heterologous booster schedules are associated with increased protection against severe, omicron related COVID-19 outcomes bmj_latest KommItEksamen boostervaccines vaccines COVID19 SARSCoV2 omicron
By Dr. Sanchari Sinha Dutta, Ph.D.Jul 26 2023Reviewed by Lily Ramsey, LLM A recent study published in the British Medical Journal compared different coronavirus disease 2019 vaccination regimens. The study reveals that heterologous booster vaccination provides more protection against severe COVID-19 than homologous booster and primary vaccination.
A drop in vaccine efficacy was observed later with the emergence of novel viral variants with improved immune fitness. To preserve vaccine efficacy, a third booster dose of COVID-19 vaccines has been introduced globally. Real-world evidence indicates that COVID-19 booster vaccination is more effective than primary vaccination in controlling the pandemic.
Comparison between booster and primary vaccination regimens Compared to primary vaccination, the AstraZeneca – Pfizer/Moderna heterologous booster vaccination showed vaccine effectiveness of 83% against COVID-19 hospitalization and 96% against disease-related mortality. Similarly, the Pfizer – Moderna heterologous booster vaccination showed vaccine effectiveness of 81% against COVID-19 hospitalization and 87% against mortality.
Comparison between heterologous and homologous vaccination regimens The AstraZeneca – Pfizer/Moderna heterologous booster vaccination showed vaccine effectiveness of 27% against COVID-19 hospitalization and 22% against disease-related mortality compared to homologous booster vaccination. Compared to homologous Pfizer booster vaccination, homologous Moderna booster vaccination showed protective efficacies of 32%, 30%, 37%, and 10% against COVID-19-related hospitalization, mortality, ICU admission, and SARS-CoV-2 infection, respectively.
Belgique Dernières Nouvelles, Belgique Actualités
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