Identification of plasma proteins associated with ovarian cancer risk SSRN cancer plasmaproteins cancerrisk risk ovariancancer womenshealth
By Pooja Toshniwal PahariaAug 8 2023Reviewed by Sophia Coveney In a recent study posted with Preprints with The Lancet to the SSRN server, researchers performed proteomic Mendelian randomization as well as co-localization analyses to identify drug targets for ovarian cancer.
About the study In the present study, researchers genetically estimated plasma proteins associated with ovarian cancer risk. Target drug databases and previously published druggable gene lists were searched to assess the druggability of the identified proteins and validate drugs. Among the proteins investigated, 27 lowered ovarian cancer risk, including retinoic acid receptor responder 1 , sialic acid-binding Ig-like lectin 9 , transmembrane protein 132A , serine peptidase inhibitor, Kunitz type 3 , contactin 2 , transforming growth factor β-induced , hepatitis A virus-cell receptor 2 , and HGF activator .
Most proteins showed causal influences on ovarian cancer risk factors, such as anthropometric characteristics , metabolic characteristics , and female reproductive characteristics . In addition, a few proteins impacted the basal metabolic rate, birth weight, blood cell counts, and breast cancer.
Belgique Dernières Nouvelles, Belgique Actualités
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