Immune checkpoint inhibitor treatment is facilitated by dietary tryptophan metabolite synthesized by Lactobacillus reuteri CellCellPress PittTweet immune immunology news research microbiology molecular diet tumor science
By Neha MathurApr 10 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Cell journal, researchers showed how a dietary tryptophan metabolite synthesized by the probiotic Lactobacillus reuteri invaded the gut-distal tumor microenvironment of melanoma patients and facilitated their immune checkpoint inhibitor treatment.
Background There is a knowledge gap regarding the mechanisms driving ICI responsiveness in cancer patients via probiotics. Also, studies have not yet deciphered whether translocated bacteria impact tumor immunity or ICI from directly within the tumor. To this end, they treated specific-pathogen-free mice with select bacterial taxa using oral gavage every day and investigated which tumor-suppressing strain increased ICI efficacy the most.
Overall, the researchers uncovered a critical microbial-host crosstalk within the TME of melanoma patients that drove spontaneous antitumor immunity and facilitated ICI in preclinical melanoma.
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