Increased Gibbs energy of binding indicates greater infectivity of SARS-CoV-2 BA.2.75 Coronavirus Disease COVID SARSCoV2 MDPIOpenAccess TU_Muenchen
By Dr. Chinta SidharthanOct 27 2022Reviewed by Benedette Cuffari, M.Sc. A recent BioTech journal study explores the thermodynamic properties, such as antigen-receptor binding rate and Gibbs energy of binding, of the severe acute respiratory syndrome coronavirus 2 Omicron subvariant BA.2.75 to understand its increased transmissibility.
The ribonucleic acid of SARS-CoV-2 has mutated to produce variants with different infectivity and immune evasion properties. SARS-CoV-2 infects the host cell by binding its spike protein trimer to the angiotensin-converting enzyme 2 receptor. The Gibbs energy of binding was calculated using the dissociation equilibrium constant, which was then used to calculate the rate of binding of the spike protein to the ACE-2 receptor for each of the SARS-CoV-2 variants. Kinetic, exponential, and thermodynamic approaches were employed to determine the entry rate for SARS-CoV-2 variants.
The BA.2.75 variant carrying the N460K mutation also had the highest entry rate of 1.49 × 10-15 M/s as compared to BA.2 and BA.5, which had rates of 6.58 × 10-17 M/s and 1.19 × 10-17 M/s, respectively. The binding rate of the SARS-CoV-2 Omicron variants increased from BA.2 to BA.5. The higher entry rate and Gibbs energy of binding for the Omicron BA.2.75 subvariant likely explain the greater infectivity of BA.2.75 as compared to other dominant subvariants BA.4 and BA.5. Moreover, these characteristics may also indicate that BA.2.75 could be the next globally dominant SARS-CoV-2 Omicron subvariant.
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