Omicron BA.4/BA.5 bivalent mRNA vaccine booster elicits similar neutralizing antibody responses to monovalent vaccine ColumbiaMed ColumbiaPS UMich mRNA vaccine vaccination Omicron SARSCoV2 COVID19 coronavirus
By Susha Cheriyedath, M.Sc.Oct 26 2022Reviewed by Danielle Ellis, B.Sc. In a study recently posted to the bioRxiv* preprint server, researchers analyzed the antibody response induced by the new bivalent messenger ribonucleic acid severe acute respiratory syndrome coronavirus 2 vaccines in individuals who have been fully vaccinated with monovalent vaccines and those who have had breakthrough infection with the SARS-CoV-2 Omicron BA.4/BA.5 variants.
Data published on neutralizing antibody responses induced by bivalent mRNA vaccines are limited to animal and human studies using a bivalent vaccine targeting the spike protein of Omicron BA.1 and the wild type strain. Despite the extensive use of the new bivalent Omicron BA.4/BA.5 mRNA vaccines as booster shots, very little information is available on the antibody responses they induce in humans.
They tested all collected sera for neutralization against the D614G ancestral SARS-CoV-2 viral strain and the Omicron BA.1/BA.2, BA.4/BA.5, BA.4.6, BA.2.75, and BA.2.75.2 sub-lineages. They also tested the sera against many related sarbecoviruses, including GD-pangolin, SARS-CoV, and WIV1. Interestingly, in the case of the three related sarbecoviruses - WIV1, SARS-CoV, and GD-Pangolin - neutralizing antibody titers of individuals who received a fourth dose of a monovalent vaccine were slightly yet significantly higher than those who received the bivalent vaccine as a fourth vaccine dose.
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