Milk antibodies against SARS-CoV-2 after booster vaccination and breakthrough infection medrxivpreprint UCSF SARSCoV2 COVID19 Booster Vaccine Vaccination
By Tarun Sai LomteDec 19 2022Reviewed by Aimee Molineux In a recent study posted to the medRxiv* preprint server, researchers longitudinally evaluated the antibody response against severe acute respiratory syndrome coronavirus 2 in lactating individuals.
The study and findings In the present study, researchers performed a longitudinal analysis of antibody response against SARS-CoV-2 in lactating individuals after two- or three-dose vaccination and breakthrough infection. Human milk samples were obtained from 33 lactating individuals double-vaccinated with a COVID-19 mRNA vaccine .
General symptoms were more likely after infection in boosted individuals with a breakthrough infection than upon vaccination. Mothers did not report infant symptoms after the booster dose. Nevertheless, eight infants, with a mean age of eight months and not exclusively breastfed at this age, were infected and had at least one symptom .
Boosted participants with a breakthrough infection had significantly higher milk IgA levels than double- or triple-vaccinated individuals. Nonetheless, IgG levels post-infection were comparable to post-boost levels. Moreover, the plasma IgA levels in lactating individuals were significantly higher post-infection than post-boost. Milk and plasma IgA antibodies positively correlated after booster vaccination, with a much stronger correlation post-infection.
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