The potential and challenges of mucosal COVID-19 vaccines NIAIDNews
On November 7th and 8th 2022, The National Institute of Allergy and Infectious Diseases , a component of the National Institutes of Health , The Coalition for Epidemic Preparedness Innovation , The Bill & Melinda Gates Foundation , The Biomedical Advanced Research and Development Authority , and the Wellcome Trust invited vaccine researchers and developers from around the world to: explore the potential of mucosal vaccines to block infection with and transmission of SARS-CoV-2; define...
Notably, there is limited data available from clinical efficacy trials to assess their impact on transmission, infection, or disease; however, several candidates appear to induce a mucosal immune response based on immune markers, such as secretory IgA and secretory IgG although the clinical significance of those markers is currently unclear.
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Frontiers | DNA immunization with in silico predicted T-cell epitopes protects against lethal SARS-CoV-2 infection in K18-hACE2 miceThe global SARS-CoV-2 pandemic caused significant global disruption, both socially and economically, despite highly effective vaccines being developed at an unprecedented speed. As the first licensed vaccines only target single B-cell antigens, antigenic drift could lead to loss of efficacy against emerging SARS-CoV-2 variants. Improvement of the B-cell vaccines by including multiple T-cell epitopes could potentially solve this challenge. Here we show that in silico predicted MHC class I/II ligands induced robust T-cell responses and protected against severe disease in genetically modified K18-hACE2/BL6 mice susceptible to SARS-CoV-2 infection.
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SARS-CoV-2 infection among infants born to maternal COVID-19 cases during Omicron variant predominanceSARS-CoV-2 infection among infants born to maternal COVID-19 cases during Omicron variant predominance JPediatr CDCgov maternalcovid covid COVID19 SARSCoV2 omicron variant spread infant childhealth
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The virological characteristics of XBB.1.16The virological characteristics of XBB.1.16 Coronavirus Disease COVID Omicron SARSCoV2 XBB116 biorxivpreprint KobeU_Global UTokyo_News_en CharlesUniPRG
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Post-COVID-19 condition and persisting symptoms in English schoolchildren: repeated surveys to March 2022 - BMC Infectious DiseasesBackground Both post-COVID-19 condition (long COVID) and the presence of persisting symptoms that do not meet formal definitions of post-COVID-19-condition may adversely affect quality of life and function. However, their prevalence among children and young people in England is unclear. Methods We used data from repeated surveys in a large cohort of English schoolchildren from the COVID-19 Schools Infection Survey (SIS) for the school year 2021/22 to describe the weighted prevalence of post-COVID-19-condition and compare persisting symptoms between individuals with a positive SARS-CoV-2 test and those with neither a positive test history nor suspected infection. Results Among 7797 children from 173 schools, 1.8% of primary school pupils (aged 4 to 11 years), 4.5% of secondary school pupils in years 7–11 (aged 11 to 16 years) and 6.9% of those in years 12–13 (aged 16 to 18 years) met a definition of post-COVID-19 condition in March 2022. Specific persisting symptoms such as anxiety or difficulty concentrating were frequently reported regardless of prior infection status and increased with age: 48.0% of primary school pupils, 52.9% of secondary school pupils in years 7–11 and 79.5% in years 12–13 reporting at least one symptom lasting more than 12 weeks. Persisting loss of smell and taste, cardiovascular and some systemic symptoms were more frequently reported by those with a previous positive test. Conclusions We showed that ongoing symptoms were frequently reported by English schoolchildren regardless of SARS-CoV-2 test results and some specific symptoms such as loss of smell and taste were more prevalent in those with a positive test history. Our study emphasises the wide-ranging impacts of the COVID-19 pandemic on the health and wellbeing of children and young people.
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Covid-19 spring booster vaccine available for most vulnerable🦠️ Covid boosters are being offered to people over 75, care home residents and those with a weakened immune system 🦠️
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