New targets for psoriasis treatment? Study reveals 165 associated genes IJMS_MDPI psoriasis genes psoriasistreatment genetics genomics
By Dr. Chinta SidharthanJul 25 2023Reviewed by Lily Ramsey, LLM In a recent study published in the International Journal of Molecular Sciences, researchers conducted a transcriptome-wide association study to understand the genetic basis of the chronic inflammatory skin disease psoriasis and identify potential drug targets.
While the pathogenesis of psoriasis has been attributed to various factors such as infections, environmental factors, and genetics, the etiology remains unclear. The pathogenetic basis of psoriasis needs to be investigated from an integrative approach for identifying potential therapeutic targets to treat or prevent psoriasis.
About the study In the present study, the researchers used data from genome-wide association study summary statistics involving individuals of European ancestry to perform TWAS to understand the underlying genetic factors of psoriasis. Based on the absence of sex-specific patterns in the prevalence of psoriasis, female-specific tissues were not selected for the eQTL panel. Various analyses, such as context-specific genetics , colocalization , and TWAS, were used to evaluate the changes in gene expression associated with genetic variants and identify potential genetic markers for psoriasis.
Functional annotation was also conducted for each tissue to identify cross-tissue or tissue-specific biological enrichments that contribute to the etiology of psoriasis. Additionally, a phenome-wide association study was performed to determine whether the genetic features related to psoriasis exhibited pleiotropic effects.
The LDSC-SEG tissue-prioritization analysis using two multi-tissue datasets resulted in the inclusion of additional types of tissue, such as the spleen, stomach, esophagus mucosa, and lymphocytes transformed by Epstein Barr virus, in the present study that was not included in previous TWAS-based studies on psoriasis.
Belgique Dernières Nouvelles, Belgique Actualités
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