New York sewer rats are easily infected by SARS-CoV-2, according to new study biorxivpreprint Mizzou NewYork USA Rats Infection SARSCoV2 Variant COVID19
By Pooja Toshniwal PahariaNov 23 2022Reviewed by Aimee Molineux In a recent study posted to the bioRxiv* preprint server, researchers evaluated severe acute respiratory syndrome coronavirus 2 exposure among rats inhabiting New York City during the fall of 2021.
To determine rat exposure to SARS-CoV-2, coronavirus disease 2019 , surveillance was conducted in Norway Rattus norvegicus rats between 13 September and 16 November 2021, during the period of Delts VOC predominance. Enzyme-linked immunosorbent assays were performed to measure immunoglobulin M or IgG antibody titers. Microneutralization assays analyzed seropositive rat sera for responses against the SARS-CoV-2 B.1 strain, Alpha VOC and Delta VOC.
Results Lab Diagnostics & Automation eBook Compilation of the top interviews, articles, and news in the last year. Download a copy today A total of 79 rats captured from three NYC sampling locations were sampled, of which 13 rats demonstrated positive IgM or IgG titers. Alpha, Delta, and Omicron VOCs led to robust SARS-CoV-2 infections in wild-type SD rats, with high replication titers in the lower and upper respiratory tracts and induction of adaptive and innate immunological responses.
Delta-infected rat lungs demonstrated the greatest RNA levels and titers of infectious SARS-CoV-2 titers at two dpi. SARS-CoV-2 antigens were also expressed in lung tissues of any VOC-infected rats at two or four dpi, with the greatest antigen expression among Delta-infected rats. All VOC infections induced expression of interferon -β, -γ, tumor necrosis factor-alpha , interleukin -1α, -1β, -6, -10, chemokine ligand 2 , and inducible protein 10 .
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