Distinct serotypes for severe acute respiratory syndrome (SARS)-related coronaviruses (CoVs).
By Tarun Sai LomteAug 29 2023Reviewed by Lily Ramsey, LLM A recent study published in hLife reported distinct serotypes for severe acute respiratory syndrome -related coronaviruses .
SARS-CoV-2 Omicron, harboring over 30 mutations, was first detected in South Africa in November 2021, and many sub-variants have since emerged at an unprecedented pace. The Omicron sub-variants continue to show convergent evolution, acquiring new mutations in the spike's receptor-binding domain , leading to escape from neutralizing antibodies .
Related StoriesSera from Delta variant-infected individuals did not neutralize SARS-CoV-1, SARS-CoV-2 Beta, and Omicron sub-variants. Likewise, samples from SARS-CoV-1-infected individuals showed high neutralizing titers against SARS-CoV-1 but did not cross-neutralize SARS-CoV-2. Given the antigenic similarities among ancestral SARS-CoV-2, Alpha, Beta, and Delta variants, these were considered in the same serotype. The lack of cross-neutralization between SARS-CoV-1, ancestral SARS-CoV-2, and Omicron sub-variants corroborated classifying Omicron as a distinct serotype.
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