Reports of Mpox disease following recent vaccination Monkeypox Mpox Fever immunity Vaccine Immunology Eurosurveillanc ITMantwerp UCT_news
By Suchandrima BhowmikDec 11 2022Reviewed by Benedette Cuffari, M.Sc. Almost 21,000 cases of Mpox, formerly known as monkeypox, have been reported in Europe as of November 22, 2022. Despite this high rate of infections, there has been a reduction in the incidence of Mpox since August 2022 due to increasing immunity levels in at-risk populations through targeted vaccination campaigns, naturally-acquired infections, and behavioral changes.
Primary preventive vaccination with the administration of the first subcutaneous dose began at the primary Belgian sexually transmitted infection clinics at the end of July. However, the second dose was delayed and not administered within the recommended 28 days interval. Therefore, the vaccine was administered through the off-label intradermal route at one-fifth of the SC dose from September 2, 2022.
A new study in Eurosurveillance aimed to analyze five Belgian patients with severe Mpox disease following PEPV or one- or two-dose off-label PPV. Whole genome sequencing, phylogenetic analysis, and single nucleotide variant analysis were also performed using the viral DNA isolated from the participants.
Localized anogenital symptoms were observed in all five participants. Three participants who received a single vaccine dose reported fever and other systemic symptoms, while two participants who received both vaccine doses did not report fever.
Belgique Dernières Nouvelles, Belgique Actualités
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