Diabetes is a condition in which the body produces too little or no insulin. Diabetics thus depend on an external supply of this hormone via injection or pump.
Researchers led by Martin Fussenegger from the Department of Biosystems Science and Engineering at ETH Zurich in Basel want to make the lives of these people easier and are looking for solutions to produce and administerOne such solution the scientists are pursuing is enclosing insulin-producing designer cells in capsules that can be implanted in the body.
The researchers have incorporated the blueprint of this bacterial ion channel into human insulin-producing cells. This lets these cells create the ion channel themselves and embed it in their membrane. "We Will Rock You" triggered roughly 70% of the insulin response within five minutes, and all of it within 15 minutes. This is comparable to the natural glucose-induced insulin response of healthy individuals, Fussenegger says.To test the system as a whole, the researchers implanted theinto mice and placed the animals so that their bellies were directly on the loudspeaker. This was the only way the researchers could observe an insulin response.
Belgique Dernières Nouvelles, Belgique Actualités
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