Researchers share results of MVA-BN-respiratory syncytial virus vaccine human challenge trial medrxivpreprint BavarianNordic RSV Vaccine Trial
By Pooja Toshniwal PahariaDec 7 2022Reviewed by Aimee Molineux In a recent study posted to the medRxiv* preprint server, researchers reported the immunogenicity, efficacy, and safety of the MVA-BN -RSV vaccine against RSV-A Memphis 37b strain in a human challenge trial.
The clinical trial was a double-blinded, phase 2a, placebo-controlled randomized clinical trial comprising healthy participants aged from 18 years to 50 years with expected RSV susceptibility [on the basis of neutralizing antibody titers] during screening. Participants were randomly allocated into two groups in a 1:1 ratio to receive either intramuscular MVA-BN-RSV vaccinations or equal volumes of placebo Tris-buffered saline vaccines.
Plaque assays were performed to assess RSV replication. Participant sera were analyzed using ELISA to measure anti-RSV immunoglobulin G and IgA titers and by PRNT to measure nAb titers against RSV-A, B. Further, ELISpot assays were performed for IFN-γ -and IL-4 PMBC enumeration as a response to RSV proteins.
Viral load from nasal wash samples was significantly lower among MVA-BN-RSV vaccinees than placebo vaccinees. Likewise, symptom scores were also lower post-MVA-BN-RSV vaccination. Serological anti-RSV IgA and IgG titers and nAb titers increased by four-fold and two-fold post-MVA-BN-RSV vaccinations, respectively, and robust cellular responses were observed, particularly against the internal RSV proteins.
Belgique Dernières Nouvelles, Belgique Actualités
Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.
Exploring immunogenicity, boosting efficacy and safety of modified vaccinia Ankara-Bavarian Nordic vaccineResearchers evaluated the immunogenicity, boosting efficacy, and safety of single-dose and two-dose MVA-BN (modified vaccinia Ankara-Bavarian Nordic) vaccinations in comparison to replicating smallpox vaccines.
Lire la suite »
Vaccine MVA-BN shows consistent, robust immunogenicity and safety resultsVaccine MVA-BN shows consistent, robust immunogenicity and safety results Efficacy Smallpox Vaccine MVABN Mpox uabmedicine BavarianNordic
Lire la suite »
Researchers explore the correlation between the dynamic shedding pattern of SARS-CoV-2 and viral loadResearchers attempted to establish an association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load, indicating its ribonucleic acid (RNA) levels, and the presence of infectious virions.
Lire la suite »
Mars was covered in a deep ocean that could have held life, say researchersMARS was once covered by a deep sea which might have harboured life, researchers believe. The Red Planet had enough water on it 4.5billion years ago to be covered entirely by an ocean between 300 …
Lire la suite »
Research reveals a novel viral strategy in modulating stress granule formation to promote virus infectionResearch reveals a novel viral strategy in modulating stress granule formation to promote virus infection PLOSPathogens UBC UCSF virus infection stressgranule viral
Lire la suite »