A new study led by researchers at the Icahn School of Medicine at Mount Sinai has revealed key differences in gut bacteria and their metabolic byproducts in infants that may predict the development of peanut allergies by mid-childhood. The findings, published online August 22 in the Journal of Allergy and Clinical Immunology, could pave the way for new strategies to prevent or treat this increasingly common food allergy.
and the metabolites they produce between children who did and did not develop a peanut allergy by around age 9.Infants who eventually developed peanut allergies had lower gut microbiome diversity during their early years.
Metabolites associated with peanut allergy development were linked to the"histidine metabolism pathway"—a process in the body that breaks down and uses the protein building block histidine. However, Dr. Bunyavanich also cautioned against drawing premature conclusions, noting,"While it's exciting to think our gut bacteria might influence our risk of developing allergies, it's crucial to note that altering a child's gut bacteria isn't yet an immediate solution. We need further research to truly harness these findings."
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