SARS-CoV-2 Omicron BA.2 less severe than Delta and original Omicron Coronavirus Disease COVID Omicron SARSCoV2 JAMANetworkOpen MassGeneralNews Harvard MinervaUni
By Bhavana KunkalikarOct 31 2022Reviewed by Benedette Cuffari, M.Sc. In a recent JAMA Network Open study, researchers estimate the severity of infection with the severe acute respiratory syndrome coronavirus 2 Omicron BA.2 subvariant compared to that caused by the Delta and Omicron variants.
More recently, several Omicron subvariants have become dominant circulating strains throughout the world, thus making it difficult to determine the severity of infections with these new subvariants. In addition, cohort studies that have sought to measure the Omicron BA.2 lineage severity have shown inconsistent results, thus necessitating further research.
By analyzing the dominance of variants on residual diagnostic tests, period barriers were identified. Delta cases occurred between June 27, 2021, and December 5, 2021. Omicron cases were identified between December 26, 2021, and February 21, 2022. The Omicron BA.2 subvariant was assigned to any case between March 21, 2022, and May 21, 2022.
Related StoriesIn-hospital mortality within 30 days since COVID-19 diagnosis was the primary outcome. Hospitalization, invasive ventilation, and ICU hospitalizations were considered secondary outcomes. The patient was classified as having secondary outcomes if these events occurred within 30 days of the COVID-19 incident date.
All three populations infected by the three assessed variants reported similar comorbidities. Notably, a significant number of cases involving individuals suffering from chronic pulmonary disease, including 4,529, 2,829, and 7,877 patients from the Omicron BA.2, Delta, and Omicron cohorts, respectively.
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