Alzheimer's disease (AD) varies widely in its age of onset, presentation and severity. Recently, the SORL1 gene has received increased attention since variations in this gene have been associated with both early and late onset AD. However, little is known about how damage to SORL1 leads to disease.
for AD, including making key discoveries related to the amyloid protein. Two novel anti-amyloid therapies, aducanumab and lecanemab, have received United States Food and Drug Administration accelerated and traditional approval, respectively, but not all patients respond to these drugs, warranting other treatment options.
The most dramatic impact was seen in neurons and a"support" cell in the brain , with neurons lacking SORL1 demonstrating especially prominent reduction in the levels of two key AD proteins: APOE and CLU. Without APOE and CLU, neurons cannot properly regulate lipids, which accumulate in droplets that may impair neurons' abilities to communicate with each other.
Belgique Dernières Nouvelles, Belgique Actualités
Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.
Stem cell DNA match sought for three-month-old boy with aggressive rare cancerJust 3,100 people are thought to be diagnosed with acute myeloid leukaemia in the UK each year.
Lire la suite »
Stem cell DNA match sought for three-month-old boy with aggressive rare cancerJust 3,100 people are thought to be diagnosed with acute myeloid leukaemia in the UK each year.
Lire la suite »
Research cytokines for stem cellsStem cells are becoming increasingly important in drug discovery and development, as such, possessing accurate cytokines to aid in stem cell research is crucial.
Lire la suite »
Intermittent fasting improves Alzheimer's pathology in mouse modelOne of the hallmarks of Alzheimer's disease is disruption to the body's circadian rhythm, the internal biological clock that regulates many of our physiological processes. Nearly 80% of people with Alzheimer's experience these issues, including difficulty sleeping and worsening cognitive function at night. However, there are no existing treatments for Alzheimer's that target this aspect of the disease.
Lire la suite »
Thousands of stem cell donors sign up to help Liverpool babyThree-month-old Francis has acute myeloid leukaemia and is in urgent need of a stem cell transplant.
Lire la suite »
Lanarkshire family to embark on dementia charity walk in memory of beloved mumThe Cambuslang family will take part in Alzheimer Scotland’s Memory Walk in September.
Lire la suite »