Researchers investigated immunologic and clinical findings indicative of SARS-CoV-2 exposure among individuals with postviral syndrome.
By Pooja Toshniwal PahariaAug 29 2023Reviewed by Sophia Coveney In a recent study published in Neurology Neuroimmunology Neuroinflammation, researchers investigated immunologic and clinical findings indicative of severe acute respiratory syndrome coronavirus 2 exposure among individuals with postviral syndrome who visited Northwestern Medicine’s Neuro COVID-19 clinic.
Moreover, SARS-CoV-2 testing may have been performed after the periods of detectable seropositivity and viral shedding in the nasopharynx of suspected individuals. The study included outpatients attending Northwestern Medicine’s clinic from June 2020 to April 2022, including 29 individuals with PVS, of which 23 and 6 were unvaccinated and vaccinated, respectively. Anti-SARS-CoV-2 B- and T lymphocyte-mediated immunological responses against SARS-CoV-2 spike receptor-binding domain and nucleocapsid proteins were measured among individuals with PVS following suspected SARS-CoV-2 infection.
Blood was withdrawn from the participants to extract serum and isolate peripheral blood mononuclear cells . Individuals with NP and PVS filled out the Patient-Reported Outcomes Measurement Information System questionnaires to provide data related to fatigue, cognitive function, depression, anxiety, and sleep disturbances.
Of 29 individuals with postviral syndrome, 41% showed detectable cell-mediated and humoral immunological responses indicative of prior SARS-CoV-2 exposure. Among 12 PVS+ individuals, 50% and 75% demonstrated anti-S and anti-N responses, respectively, highlighting the importance of multitargeted COVID-19 immunologic evaluation and the limitations of commercially available diagnostic tests.
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