Study finds several flavor/fragrance compositions that inhibit vRBD-hACE2 binding PLOSONE flavor fragrance compounds chemicals COVID19 coronavirus covid ACE2
By Dr. Sanchari Sinha Dutta, Ph.D.Dec 20 2022Reviewed by Danielle Ellis, B.Sc. A study published in the journal PLOS ONE describes the antiviral activity of flavor/fragrance compositions against severe acute respiratory syndrome coronavirus 2 . Flavor/fragrance compositions exhibit an antiviral effect by blocking viral entry into host cells.
Flavors and fragrances are organic compounds with distinctive tastes and pleasant odors. Many flavor/fragrance compositions are widely used because of many beneficial effects, including relaxing and refreshing effects. These compositions are safe and inexpensive and are mainly used as food additives, perfumes, and ingredients of daily commodities.
SARS-CoV-2 variants with spike RBD mutations that emerged during the pandemic have shown significantly higher viral fitness than the original strain with wildtype RBD. Considering this, scientists selected 8 representative flavor/fragrance compositions and tested their ability to inhibit the interactions between different RBD mutants and ACE2.
Among selected 8 representative flavor/fragrance compositions, 4 were less cytotoxic, and the other 4 were cytotoxic.
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