Study highlights COVID-19 vaccine safety among children Vaccines Vaccination Immunization AdverseEvents COVID19 Boosters Medical SARSCoV2 PLOSONE
By Pooja Toshniwal PahariaFeb 23 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the journal PLoS ONE, researchers evaluate coronavirus disease 2019 vaccine-associated composite serious adverse events following immunization among five- to 17-year-old children in the United States to ascertain the composite reported risk associated with vaccination.
As SARS-CoV-2 infections become endemic, which increases the risk of long COVID, vaccination safety data could be utilized to reassure parents, as well as primary care and population health professionals, to inform patients and enhance trust in COVID-19 vaccines. Timely and precise documentation of adverse events is paramount to dismissing misinformation and confusion.
The national VAERS database included information on demographic variables, residence, COVID-19 vaccination date, adverse event documentation date, COVID-19 symptoms, disability, and recovery. The prime study exposures were COVID-19 vaccines, of which included Pfizer-BioNTech for pediatric patients, as well as the Moderna mRNA-1273, Janssen Ad26.COV2.S and BNT-162b2 vaccines for adult individuals.
Study findings During the study period, 467,890,599 SARS-CoV-2 vaccines were provided to five- to 65-year-old U.S. residents, with 180,581,278 who had received more than two vaccine doses. A total of 177,679 AEFI were documented by VAERS, 18% of which were serious. Men had greater sAEFI rates than females. IRRs for age-gender interactions, with women between 18 and 65 years of age for reference, showed greater hospitalization rates for males aged 12 to 17 years .
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