Researchers evaluated distinct immune responses to mRNA and vector-based COVID-19 vaccines and natural SARS-CoV-2 infections.
By Neha MathurAug 17 2023Reviewed by Sophia Coveney In a recent article published in Scientific Reports, researchers evaluated distinct immune responses to messenger ribonucleic acid and vector-based coronavirus disease 2019 vaccines, and natural severe acute respiratory syndrome coronavirus 2 infections.
IgG is the most abundant immunoglobulin isotype in human serum. Each subclass of IgG has a unique profile related to antigen binding, immune complex formation, complement activation, and triggering of effector cell activation. In another study, it was suggested that adenovirus-based vaccines do not elicit a long-term S-specific IgG4 response.
The team collected serum samples on median day 128 post-booster vaccination and from CONV and HOSP patients on median days 54 and 21, respectively. They also monitored 15 mRNA-vaccinated volunteers on median days 37 and 160 post-booster. Regarding the pattern of IgG subclasses, it was comparable for individuals infected before mRNA vaccinations and those who received vector-based vaccines, and even for COVID-19 patients who received no vaccine. COVID-19 patients predominantly had S-specific IgG1/G3 subclasses in serum on the median of 21 days post-infection.
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