Northwestern Medicine scientists have discovered how HIV hijacks intracellular processes to proliferate and contribute to neurodegeneration, according to a new study published in Nature Communications.
is highly expressed in macrophages and microglia and restricts HIV-1 replication. To counteract this, HIV-1 promotes APP processing which ultimately results in the production of toxic beta-amyloids that contribute to HAND, according to Naghavi's previous research.
In the current study, Naghavi and her collaborators sought to identify the underlying mechanisms of APP's antiviral function. Naghavi and her collaborators found that the processing of APP occurs within subsets of multivesicular bodies that are also required for HIV-1 replication, according to the study.
After making this discovery, Naghavi and her collaborators treated cultured cells with a clinically approved inhibitor of the APP processing pathway and found that it successfully blocked HIV-1's access to the MVBs, thereby suppressing viral replication in microglia and macrophages.
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