The EAT-Lancet diet, genetic susceptibility and risk of atrial fibrillation in a population-based cohort - BMC Medicine

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The EAT-Lancet diet, genetic susceptibility and risk of atrial fibrillation in a population-based cohort - BMC Medicine
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A study in BMCMedicine finds that higher adherence to the EAT-Lancet diet index is associated with a lower risk of atrial fibrillation among Swedish adults, especially in those with a higher genetic risk, though gene-diet interaction is not significant.

) × , where SNP indicates the risk allele number of each SNP . The calculated GRS of AF ranged from 76.6 to 128.7, and Additional file

], where the dietary interview was shortened from 60 to 45 min, resulted in the variable “method .” The variable “season” refers to the time of year the baseline diet data collection took place . In order to examine the robustness of the results, we conducted a series of sensitivity analyses. First, considering that diabetes might cause important diet changes, we excluded those with prevalent diabetes . Second, to better reflect usual dietary intakes, we excluded potential energy misreporters and individuals that had reported a substantial eating habit change in the past .

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Risk of hip fracture in meat-eaters, pescatarians, and vegetarians: a prospective cohort study of 413,914 UK Biobank participants - BMC MedicineRisk of hip fracture in meat-eaters, pescatarians, and vegetarians: a prospective cohort study of 413,914 UK Biobank participants - BMC MedicineBackground Meat-free diets may be associated with a higher risk of hip fracture, but prospective evidence is limited. We aimed to investigate the risk of hip fracture in occasional meat-eaters, pescatarians, and vegetarians compared to regular meat-eaters in the UK Biobank, and to explore the role of potential mediators of any observed risk differences. Methods Middle-aged UK adults were classified as regular meat-eaters (n = 258,765), occasional meat-eaters (n = 137,954), pescatarians (n = 9557), or vegetarians (n = 7638) based on dietary and lifestyle information at recruitment (2006–2010). Incident hip fractures were identified by record linkage to Hospital Episode Statistics up to September 2021. Multivariable Cox regression models were used to estimate associations between each diet group and hip fracture risk, with regular meat-eaters as the reference group, over a median follow-up time of 12.5 years. Results Among 413,914 women, 3503 hip fractures were observed. After adjustment for confounders, vegetarians (HR (95% CI): 1.50 (1.18, 1.91)) but not occasional meat-eaters (0.99 (0.93, 1.07)) or pescatarians (1.08 (0.86, 1.35)) had a greater risk of hip fracture than regular meat-eaters. This is equivalent to an adjusted absolute risk difference of 3.2 (1.2, 5.8) more hip fractures per 1000 people over 10 years in vegetarians. There was limited evidence of effect modification by BMI on hip fracture risk across diet groups (pinteraction = 0.08), and no clear evidence of effect modification by age or sex (pinteraction = 0.9 and 0.3, respectively). Mediation analyses suggest that BMI explained 28% of the observed risk difference between vegetarians and regular meat-eaters (95% CI: 1.1%, 69.8%). Discussion Vegetarian men and women had a higher risk of hip fracture than regular meat-eaters, and this was partly explained by their lower BMI. Ensuring adequate nutrient intake and weight management are therefore particularly important in vegetarians in the context of hip
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