The effects of vitamin C, vitamin E, and β-carotene on the gut microbiota gut microbiome vitamins vitamin gutmicrobiome
By Dr. Chinta SidharthanMay 4 2023Reviewed by Danielle Ellis, B.Sc. In a recent review published in the journal Food Research International, researchers reviewed the impact of vitamins C and E and β-carotene on the gut microbiome to understand how known vitamins modify the gut microbiota.
Vitamins C and E and β-carotene have antioxidant properties and protect cellular components by blocking reactive free radicals. Vitamin C is also essential for the normal functioning of the central nervous system, while vitamin E is important for the protection of cellular membranes from free-radical damage.
Hypertension is believed to be linked to gut microbiome dysbiosis. In mouse models of hypertension, supplementation with vitamin C improved the richness and diversity of the gut microbiome, reduced oxidative stress and inflammation, and lowered blood pressure.
Studies in animal models reported improvements in the abundance of Ruminococcaceae, Lachnospiraheae, and Roseburia after supplementation with tocopherols. In mouse models of colitis-associated colon cancer, diets supplemented with vitamin E significantly altered the β-diversity and composition of the gut microbiome. In vitro studies have also shown an increase in the abundance of Firmicutes, and Actinobacteria and decreased abundance of Bacteriodetes associated with vitamin E supplementation.
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