A study published in the Orphanet Journal of Rare Diseases finds that increased total choline intake is related to improved working memory outcomes among adults with well controlled phenylketonuria. Larger studies are warranted.
], an index of dietary control was computed as the mean of all half-year median Phe concentrations for early childhood , middle childhood , adolescence , adulthood , and across the lifetime . In the case of small gaps in records, values were extrapolated using linear regression and Phe levels of adjacent years for purposes of IDC calculation. In cases of larger gaps, the participant was excluded from analysis of the relevant developmental epoch.
To evaluate the association between metabolic control and working memory performance, bivariate correlation analyses were conducted for concurrent Phe, Phe average from the year prior to the study, and all IDC measures . To adjust for multiple comparisons, the false discovery rate procedure of Benjamini and Hochberg was applied [].
An additional multivariable regression analysis was conducted that adjusted for both current and historical metabolic control. IDC from middle childhood was utilized as the historical measure of metabolic control given the present study identified a significant correlation between this IDC measure and the working memory composite.
Given these regression analyses modeled choline differently than the ANCOVA in the full sample , a sensitivity analysis was conducted to determine if both statistical approaches would produce consistent results. For this analysis, the aforementioned multivariable regression models were evaluated with choline modeled as a dichotomous variable based on the alternative AI.values ≤ 0.05 were considered statistically significant, and.
Belgique Dernières Nouvelles, Belgique Actualités
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