Unlocking the immune puzzle: study evaluates the immune impact of second booster COVID-19 vaccine SciReports immunity immunology booster boostervaccine vaccine vaccination covid COVID SARSCoV2
By Pooja Toshniwal PahariaJul 6 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Scientific Reports Journal, researchers assessed acute respiratory syndrome coronavirus 2 Delta variant of concern and Omicron VOC neutralization by serum samples obtained from vaccinees.
Monoclonal antibodies are inefficient against current Omicron strains, and vaccine-preventable illnesses are increasing. About the study In the present study, researchers investigated and evaluated the impact of the fourth vaccination on humoral immune responses. To assess the second booster’s effects on the breadth of the SARS-CoV-2 spike glycoprotein-targeted immunological responses, antibody binding to Delta and Omicron was examined, and the relative binding ratio between the SARS-CoV-2 VOCs and the ancestral Wuhan-Hu1 strain was determined.
For Omicron, six months after the fourth vaccination, the titer returned to the same low neutralizing capacity as six months after the third vaccination.
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