New research out of the University of Texas Medical Branch potentially points to an effective treatment for Lassa fever, a dangerous, often fatal disease common to much of West Africa but considered a major threat to global health.
In a paper published in the journal Proceedings of the National Academy of Sciences, UTMB's scientists document how a new drug from Zalgen Labs successfully cured cynomolgus monkeys infected with Lassa virus.
Exposure to infected animals is the most common cause of infection in humans. A recent study that identified the top 50 agents with pandemic potential, Lassa fever was ranked first among known viruses regarded as a threat for zoonotic spillover. Lassa virus has a high level of genetic diversity across much of West Africa. This creates a real challenge for therapeutic developers as it raises the question of whether a single drug could be used to treat all Lassa virus infections."
The study concluded that the Arevirumab-3 therapeutic successfully treated cynomolgus monkeys when administered beginning at advanced stages of disease caused by two different major strains of Lassa virus that were involved in the research.
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