What are the associations of metabolome, microbiome, and immune perturbations with severe COVID-19? biorxivpreprint ChariteBerlin COVID19 SARSCoV2 Metabolome Microbiome
By Tarun Sai LomteDec 8 2022Reviewed by Aimee Molineux In a recent study posted to the bioRxiv* preprint server, researchers observed that coronavirus disease 2019 progression and inflammatory responses are associated with changes in the metabolome and microbiome.
The study and findings In the present study, researchers characterized the interplay between the immune system, metabolome, and microbiome, by applying an integrated systems approach using longitudinal samples from COVID-19 patients and controls. The study included a subset of subjects enrolled in the prospective COVID-19 patient cohort between March and June 2020.
The researchers performed metabolomic analyses of urine and plasma, whole metagenome sequencing of TBS, OP, and stool specimens, single-cell ribonucleic acid sequencing of PBMCs, quantitative reverse-transcription polymerase chain reaction of OP samples, and multiplex enzyme-linked immunosorbent assay of plasma cytokines.
Interferons , tumor necrosis factor -α, interleukin -10, and several inflammatory cytokines were elevated in the plasma of COVID-19 patients relative to controls. IFNs declined in the later clinical course, whereas inflammatory cytokines remained persistently elevated in patients with severe illness. Classical monocytes were elevated in severe COVID-19 patients compared to mild COVID-19 patients and controls.
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