When is it best to use dose-sparing vaccination strategies for monkeypox to protect more people? medrxivpreprint fredhutch UW vaccination vaccine monkeypox virus
By Tarun Sai LomteNov 17 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the medRxiv* preprint server, researchers evaluated dose-sparing strategies for monkeypox vaccination using mathematical modeling.
The study and findings In the current study, researchers used mathematical modeling to explore scenarios wherein fractional dosing of the MVA vaccine would be optimal. The model of MPX transmission among the MSM population in Seattle, Washington, was adopted from the model of human immunodeficiency virus transmission. The population comprised 65,000 men, categorized into age groups and risk groups. There were around 8,000 men in the high-risk group with a greater need to vaccinate.
Related StoriesWhen only 2500 vaccine vials were available, sufficient for 31% of high-risk individuals, dose-sparing prevented more infections than full-dose immunization if the fractional dose VE was > 34%. In this scenario, 13% fewer infections were projected when dose-sparing was implemented. In this same case, with more vaccines available , dose-sparing and full-dose strategies would have been comparable in effect, but the dose-sparing strategy would cause 5.3% more infections at the peak. In the optimistic scenario of equivalent VE of fractional and full-dose vaccine with limited supply , fractional dosing was projected to prevent 30% or more infections than no vaccination over six months.
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