In a BMC_series blog post, BMC Ecology and Evolution announces that it is a Peer Community In (PCI) friendly journal and calls for submission of articles recommended by PCI Ecology, PCI Evolutionary Biology and PCI Paleontology.
The BMC Series is committed to continual innovation in research publishing to better support the needs of our communities, ensuring the integrity of the research we publish and championing the benefits of open research for all. In line with this mission, BMC Ecology and Evolution is delighted to welcome the submission of articles recommended by the Peer Community In platform.
A PCI recommender determines the recommendation of an article based on at least two peer review reports. Author’s may wish to publish their PCI recommended manuscript within the BMC Series to validate that their manuscript has undergone full peer review and ensure that their research reaches a broad audience via inclusion in the best-known indexing services.
Belgique Dernières Nouvelles, Belgique Actualités
Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.
Management of penile post-circumcision ischemia by pentoxifylline infusion and hyperbaric oxygen therapy - BMC UrologyBackground Post-circumcision penile ischemia is a devastating complication. We will present our experience in managing children with various forms of penile ischemia. Materials and methods This cohort prospective observational and interventional study was performed on all male children with post-circumcision penile ischemia between April 2017 and October 2021. A designed and approved protocol includes a combination of early pentoxifylline infusion, hyperbaric oxygen inhalation, early catheterization, and appropriate surgical debridement were applied for patients with deep ischemia 11/23, mainly the necrotic skin and subcutaneous tissues. Data of patient age, anesthesia method, monopolar diathermy usage, early presentation and positive wound culture were collected and analyzed statistically. Results During the study period 3,382 children were circumcised for non-medical reasons; 23 children were diagnosed with penile ischemia (0.7%), among other complications (9%). Most of the penile ischemia is associated with the use of monopolar diathermy (74%). The use of compressive wound dressing to control post-circumcision bleeding and infections is also responsible for ischemia in 52.2% and 43.5% of the cases. Inexperienced physicians were commonly responsible for ischemia (73.9%). Patients managed at first 24 h had better outcomes than those who were presented later (p = 0.001). Conclusion In children with post-circumcision penile ischemia, a combination of hyperbaric oxygen therapy and pentoxifylline is especially effective for patients with skin and facial necrosis, this management reduces penile tissue loss.
Lire la suite »
Pikmin 4 review - Nintendo's strategy series reaches near-perfect evolutionThe Pikmin series blossoms anew, in a bouquet of fresh gameplay and the best of its roots. Eurogamer's Pikmin 4 review:
Lire la suite »
Gundam Evolution server closure to discontinue all Xbox achievementsBandai Namco is shutting down Gundam Evolution's servers later this year, despite the free-to-play first-person shooter launching in late 2022.
Lire la suite »
Gundam Evolution shutting down, launched less than a year agoA little under a year since it made its debut, Bandai Namco has announced Gundam Evolution is shutting down.
Lire la suite »
Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice - BMC MedicineBackground Genome-wide association studies (GWAS) have reported single-nucleotide polymorphisms (SNPs) in the VRK serine/threonine kinase 2 gene (VRK2) showing genome-wide significant associations with major depression, but the regulation effect of the risk SNPs on VRK2 as well as their roles in the illness are yet to be elucidated. Methods Based on the summary statistics of major depression GWAS, we conducted population genetic analyses, epigenome bioinformatics analyses, dual luciferase reporter assays, and expression quantitative trait loci (eQTL) analyses to identify the functional SNPs regulating VRK2; we also carried out behavioral assessments, dendritic spine morphological analyses, and phosphorylated 4D-label-free quantitative proteomics analyses in mice with Vrk2 repression. Results We identified a SNP rs2678907 located in the 5’ upstream of VRK2 gene exhibiting large spatial overlap with enhancer regulatory marks in human neural cells and brain tissues. Using luciferase reporter gene assays and eQTL analyses, the depression risk allele of rs2678907 decreased enhancer activities and predicted lower VRK2 mRNA expression, which is consistent with the observations of reduced VRK2 level in the patients with major depression compared with controls. Notably, Vrk2−/− mice exhibited depressive-like behaviors compared to Vrk2+/+ mice and specifically repressing Vrk2 in the ventral hippocampus using adeno-associated virus (AAV) lead to consistent and even stronger depressive-like behaviors in mice. Compared with Vrk2+/+ mice, the density of mushroom and thin spines in the ventral hippocampus was significantly altered in Vrk2−/− mice, which is in line with the phosphoproteomic analyses showing dysregulated synapse-associated proteins and pathways in Vrk2−/− mice. Conclusions Vrk2 deficiency mice showed behavioral abnormalities that mimic human depressive phenotypes, which may serve as a useful murine model for studying the pathophysiology of depression.
Lire la suite »
The global prevalence of sexual dysfunction in obese and overweight women: a systematic review and meta-analysis - BMC Women's HealthBackground Obesity is a pressing public health risk issue worldwide. Women, in particular, face a higher risk of obesity. Recent research has highlighted the association between obesity and female sexual dysfunction. Therefore, the objective of this study is to investigate the global prevalence of sexual dysfunction in obese and overweight women through a systematic review and meta-analysis. Methods In this study, a systematic search was conducted across electronic databases, including PubMed, Scopus, Web of Science, Embase, ScienceDirect, and Google Scholar. The search aimed to identify studies published between December 2000 and August 2022 that reported metabolic syndrome's impact on female sexual dysfunction. Results The review included nine studies with a sample size of 1508 obese women. The I2 heterogeneity index indicated high heterogeneity (I2: 97.5). As a result, the random effects method was used to analyze the data. Based on this meta-analysis, the prevalence of sexual dysfunction in women with obesity was reported as 49.7% (95%CI: 35.8–63.5). Furthermore, the review comprised five studies involving 1411 overweight women. The I2 heterogeneity test demonstrated high heterogeneity (I2: 96.6). Consequently, the random effects model was used to analyze the results. According to the meta-analysis, the prevalence of sexual dysfunction in overweight women was 26.9% (95% CI: 13.5–46.5). Conclusion Based on the results of this study, it has been reported that being overweight and particularly obese is an important factor affecting women's sexual dysfunction. Therefore, health policymakers must acknowledge the significance of this issue in order to raise awareness in society about its detrimental effect on the female population.
Lire la suite »