A new study led by researchers at the Icahn School of Medicine at Mount Sinai has revealed key differences in gut bacteria and their metabolic byproducts in infants that may predict the development of peanut allergies by mid-childhood.
Reviewed by Megan Craig, M.Sc.Aug 29 2023 The findings, published online August 22 in the Journal of Allergy and Clinical Immunology, could pave the way for new strategies to prevent or treat this increasingly common food allergy.
The multi-center longitudinal study monitored infants known to be at risk for allergies but who hadn't yet developed a peanut allergy. By analyzing fecal samples from infancy and later in childhood, the researchers were able to identify specific differences in gut bacteria and the metabolites they produce between children who did and did not develop a peanut allergy by around age 9.
However, Dr. Bunyavanich also cautioned against drawing premature conclusions: "While it's exciting to think our gut bacteria might influence our risk of developing allergies, it's crucial to note that altering a child's gut bacteria isn't yet an immediate solution. We need further research to truly harness these findings."
Related StoriesThe study is one of the first of its kind to longitudinally track changes in gut bacteria and their byproducts from infancy to childhood, specifically in relation to peanut allergy development. The insights gleaned could lead to innovative approaches, such as probiotics or dietary interventions, to manage and prevent peanut allergies in children, improving countless lives.
The researchers acknowledge that while their findings present strong associations between the gut environment and peanut allergy development, it's not yet confirmed that these bacterial changes directly cause the allergy. Future studies with expanded sample sizes and clinical trials will be essential to strengthen these links.Journal reference:Chun, Y., et al. Longitudinal dynamics of the gut microbiome and metabolome in peanut allergy development. Journal of Allergy and Clinical Immunology.
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Researchers uncover early signs in gut bacteria that could predict peanut allergy developmentA new study led by researchers at the Icahn School of Medicine at Mount Sinai has revealed key differences in gut bacteria and their metabolic byproducts in infants that may predict the development of peanut allergies by mid-childhood. The findings, published online August 22 in the Journal of Allergy and Clinical Immunology, could pave the way for new strategies to prevent or treat this increasingly common food allergy.
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