Gore's new 2-Layer Gore-Tex Laminates are PFC-Free, set to form the basis of Patagonia's Waterproof Jackets as of Autumn/Winter 2023
, W. L. Gore & Associates announced its plans to introduce two new 2-layer Gore-Tex Laminates with Bionic textile made from plastic waste partially collected from coastal environments. The new PFC-free Laminates are intended to be used in waterproof clothing, with the first jackets to be sold by Patagonia in Autumn/Winter of 2023.Gore Shakedry is to be discontinued
Hence, the development of new 2-layer Gore-Tex Laminates set to be used in the brand’s coming waterproof clothing that will be covered by their renowned GUARANTEED TO KEEP YOU DRY Promise.
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Molecular identity of proprioceptor subtypes innervating different muscle groups in mice - Nature CommunicationsThe molecular basis of proprioceptive neuron subtype identities is not fully understood. Here the authors investigate diversity of proprioceptive neurons connected to different muscles at the molecular level, and show that acquisition of muscle-type identity precedes the emergence of receptor character and contains effectors controlling muscle connectivity.
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Identification of herbal teas and their compounds eliciting antiviral activity against SARS-CoV-2 in vitro - BMC BiologyBackground The SARS-CoV-2/COVID-19 pandemic has inflicted medical and socioeconomic havoc, and despite the current availability of vaccines and broad implementation of vaccination programs, more easily accessible and cost-effective acute treatment options preventing morbidity and mortality are urgently needed. Herbal teas have historically and recurrently been applied as self-medication for prophylaxis, therapy, and symptom alleviation in diverse diseases, including those caused by respiratory viruses, and have provided sources of natural products as basis for the development of therapeutic agents. To identify affordable, ubiquitously available, and effective treatments, we tested herbs consumed worldwide as herbal teas regarding their antiviral activity against SARS-CoV-2. Results Aqueous infusions prepared by boiling leaves of the Lamiaceae perilla and sage elicit potent and sustained antiviral activity against SARS-CoV-2 when applied after infection as well as prior to infection of cells. The herbal infusions exerted in vitro antiviral effects comparable to interferon-β and remdesivir but outperformed convalescent sera and interferon-α2 upon short-term treatment early after infection. Based on protein fractionation analyses, we identified caffeic acid, perilla aldehyde, and perillyl alcohol as antiviral compounds. Global mass spectrometry (MS) analyses performed comparatively in two different cell culture infection models revealed changes of the proteome upon treatment with herbal infusions and provided insights into the mode of action. As inferred by the MS data, induction of heme oxygenase 1 (HMOX-1) was confirmed as effector mechanism by the antiviral activity of the HMOX-1-inducing compounds sulforaphane and fraxetin. Conclusions In conclusion, herbal teas based on perilla and sage exhibit antiviral activity against SARS-CoV-2 including variants of concern such as Alpha, Beta, Delta, and Omicron, and we identified HMOX-1 as potential therapeutic target. Given
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Prevalence of pharmacological and non-pharmacological coping mechanisms for anxiety management during the COVID-19 pandemic: investigating the transition to online learning among medical students - BMC PsychiatryBackground The coronavirus disease 2019 (COVID-19) pandemic had a devastating effect on college students worldwide. Here, the authors aimed to determine the prevalence of anxiety and its related coping strategies, provide a theoretical basis for understanding self-prescription, and identify the factors contributing to stress and anxiety in medical students during the pandemic. Methods The authors conducted a cross-sectional study among medical students in Saudi Arabia from September to November 2020. They assessed anxiety using the GAD-7 scale based on seven core symptoms. The authors also examined perceived psychological stress using a single-item measure of stress, the factors contributing to stress during the transition to online learning and examinations, and related coping strategies. The Statistical Package for Social Sciences (SPSS) version 26.0 was used to examine the data for both descriptive and inferential analyses. Chi-square test, one-way ANOVA, and univariate linear regression were used to test the research hypotheses. Results The authors collected and analyzed data from 7116 medical students distributed across 38 medical colleges. Among them, 40% reported moderate to severe anxiety symptoms. Pre-clinical and female students experienced more stress than clinical and male students. 12.19% (n = 868) of respondents reported using medication during their college years. Among those, 58.9% (n = 512) had moderate to severe anxiety, and the most commonly used drug was propranolol (45.4%, n = 394). Among the studied sample, 40.4% (n = 351) decreased their medication use after switching to online teaching. Most students used these medications during the final exam (35.8%, n = 311) and before the oral exam (35.5%, n = 308). In terms of coping strategies, males were much more likely to use substances than females, who mainly resorted to other strategies. Conclusions This study provides a national overview of the impact of COVID-19 on the mental health of medical s
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Gore-Tex Laminates with Recycled Ocean Plastic are Future of Gore's Waterproof ClothingGore's new 2-Layer Gore-Tex Laminates are PFC-Free, set to form the basis of Patagonia's Waterproof Jackets as of Autumn/Winter 2023
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