Investigating increased healthcare usage after SARS-CoV-2 infection CMAJ ICESOntario Healthcare SARSCoV2 COVID19 Infection Pandemic
By Tarun Sai LomteOct 20 2022Reviewed by Aimee Molineux In a recent study published in the Canadian Medical Association Journal, researchers evaluated the post-acute burden of healthcare use after severe acute respiratory syndrome coronavirus 2 infection in adults.
Clinicians, healthcare policymakers, and funders require an explicit understanding of the burden of PASC on the use of healthcare resources for equitable resource allocation. The study outcomes were healthcare encounters – days hospitalized, days under long-term care, home care visits, in-person or virtual outpatient encounters, and emergency department visits. Follow-up commenced eight weeks post-index date until death or September 30, 2021, whichever was first.
Findings More than 3.7 million adults were tested for COVID-19 using PCR tests in Ontario from January 2020 to March 2021. Of over 3.6 million individuals included in the study, 7.4% had positive test results, with an average follow-up time of 240 days. The matched cohort consisted of 531,702 individuals.
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Hesitancy for receiving regular SARS-CoV-2 vaccination in UK healthcare workers: a cross-sectional analysis from the UK-REACH study - BMC MedicineBackground Regular vaccination against SARS-CoV-2 may be needed to maintain immunity in ‘at-risk’ populations, which include healthcare workers (HCWs). However, little is known about the proportion of HCWs who might be hesitant about receiving a hypothetical regular SARS-CoV-2 vaccination or the factors associated with this hesitancy. Methods Cross-sectional analysis of questionnaire data collected as part of UK-REACH, a nationwide, longitudinal cohort study of HCWs. The outcome measure was binary, either a participant indicated they would definitely accept regular SARS-CoV-2 vaccination if recommended or they indicated some degree of hesitancy regarding acceptance (probably accept or less likely). We used logistic regression to identify factors associated with hesitancy for receiving regular vaccination. Results A total of 5454 HCWs were included in the analysed cohort, 23.5% of whom were hesitant about regular SARS-CoV-2 vaccination. Black HCWs were more likely to be hesitant than White HCWs (aOR 2.60, 95%CI 1.80–3.72) as were those who reported a previous episode of COVID-19 (1.33, 1.13–1.57 [vs those who tested negative]). Those who received influenza vaccination in the previous two seasons were over five times less likely to report hesitancy for regular SARS-CoV-2 vaccination than those not vaccinated against influenza in either season (0.18, 0.14–0.21). HCWs who trusted official sources of vaccine information (such as NHS or government adverts or websites) were less likely to report hesitancy for a regular vaccination programme. Those who had been exposed to information advocating against vaccination from friends and family were more likely to be hesitant. Conclusions In this study, nearly a quarter of UK HCWs were hesitant about receiving a regular SARS-CoV-2 vaccination. We have identified key factors associated with hesitancy for regular SARS-CoV-2 vaccination, which can be used to identify groups of HCWs at the highest risk of vaccine hesitancy and tailor
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Differential effects of SARS-CoV-2 variants on children and adolescentsA recent Emerging Infectious Diseases journal study evaluated whether specific SARS-CoV-2 variants were linked with different clinical manifestations in children and adolescents.
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Rapid and robust pipeline for developing mRNA vaccines for future SARS-CoV-2 variantsA recent study under review at the journal Scientific Reports and currently available on the Research Square* preprint server reported the development of a robust pipeline for fabricating an mRNA vaccine portfolio to combat current and future coronavirus outbreaks, other infectious diseases, and cancer.
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