A Review in the Journal of Neuroinflammation summarizes key factors and mechanisms contributing to lysosomal acidification impairment, the associated dysfunction in microglia, and how these defects contribute to neuroinflammation and neurodegeneration.
Factors affecting microglial lysosomal acidification and associated phagocytic and autophagic function.Presenilin-1 deficient in phosphorylation at Ser367 leads to reduced ATP6V0a1 levels, impairing lysosomal acidification. Furthermore, PS1 S367A reduces binding to Annexin A2 and decreases VAMP8 binding to autophagosomal Syntaxin 17, thereby preventing autophagosome-lysosome fusion, leading to autophagic inhibition.
Extracellular ATP activate P2X7R, leading to influx of Ca, accumulation of autophagosomes, elevation of lysosomal pH as well as increased cytokine release via inflammasome. On the other hand, inhibition of P2X4R by TNP-ATP results in increased cytokine release, while activation of P2X4R by ivermectin improves lysosomal acidification and promotes microglial function.
Belgique Dernières Nouvelles, Belgique Actualités
Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.
New trends in brain tumor immunity with the opportunities of lymph nodes targeted drug delivery - Journal of NanobiotechnologyLymph nodes targeted drug delivery is an attractive approach to improve cancer immunotherapy outcomes. Currently, the depth of understanding of afferent and efferent arms in brain immunity reveals the potential clinical applications of lymph node targeted drug delivery in brain tumors, e.g., glioblastoma. In this work, we systematically reviewed the microenvironment of glioblastoma and its structure as a basis for potential immunotherapy, including the glial-lymphatic pathway for substance exchange, the lymphatic drainage pathway from meningeal lymphatic vessels to deep cervical lymph nodes that communicate intra- and extracranial immunity, and the interaction between the blood–brain barrier and effector T cells. Furthermore, the carriers designed for lymph nodes targeted drug delivery were comprehensively summarized. The challenges and opportunities in developing a lymph nodes targeted delivery strategy for glioblastoma using nanotechnology are included at the end.
Lire la suite »
Why it matters where your data is storedEuropean data storage firms are emerging that promise to protect customer data from US interference.
Lire la suite »
I feel 10 years older since having a baby a year ago - women really do age fastest in their 30sWhen I look back at photos now of the final few weeks of my pregnancy, I simply cannot get over how young I looked compared with what I see in the mirror now Let me tell you, that pregnancy “glow” fades fast when you have a newborn, writes RoseStokes
Lire la suite »
Pop Architecture, Australia: Wallpaper* Architects’ Directory 2023The Wallpaper* Architects’ Directory 2023 includes Pop Architecture, a young Australian practice joining our annual round-up of exciting emerging architecture studios
Lire la suite »
New trends in brain tumor immunity with the opportunities of lymph nodes targeted drug delivery - Journal of NanobiotechnologyLymph nodes targeted drug delivery is an attractive approach to improve cancer immunotherapy outcomes. Currently, the depth of understanding of afferent and efferent arms in brain immunity reveals the potential clinical applications of lymph node targeted drug delivery in brain tumors, e.g., glioblastoma. In this work, we systematically reviewed the microenvironment of glioblastoma and its structure as a basis for potential immunotherapy, including the glial-lymphatic pathway for substance exchange, the lymphatic drainage pathway from meningeal lymphatic vessels to deep cervical lymph nodes that communicate intra- and extracranial immunity, and the interaction between the blood–brain barrier and effector T cells. Furthermore, the carriers designed for lymph nodes targeted drug delivery were comprehensively summarized. The challenges and opportunities in developing a lymph nodes targeted delivery strategy for glioblastoma using nanotechnology are included at the end.
Lire la suite »
Curran: Bailey Zappe, Pats' quality control worth watching vs. TexansWill Bailey Zappe distinguish himself? Will the offense operate without dysfunction? Here’s what Tom E. Curran is watching for in the Patriots’ preseason opener vs. Houston.
Lire la suite »