The association between the maturation of the infant gut microbiome and the infant immune system.
By Dr. Liji Thomas, MDAug 30 2023Reviewed by Lily Ramsey, LLM A new study published in the Nature Communications Journal examines the association between the maturation of the infant gut microbiome and the infant immune system.
Four types of allergy share the same etiology, with raised immunoglobulin E and inappropriately activated type 2 inflammatory responses. The four conditions comprise atopic dermatitis, asthma, food allergy, and allergic rhinitis. They also follow a pattern in their onset called the Allergic March. After adjustment for confounding factors, the scientists found that males were at 85% higher risk, while it was increased by 60% in those with a parental history of atopic disease.
Related StoriesA subset of children, including about half the subset, had their gut microbiome maturation pattern analyzed by shotgun metagenomics and metabolomics. This showed that maturation at one year was linked to allergies in childhood. Some of these were further linked to specific exposures, such as antibiotic use, breastfeeding, and atopic history in the father.
Thus, the restriction of TA abundance via microbiota shifts might be a key element of immune tolerance developing during infancy.
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