Study unlocks potential breakthrough in type 1 diabetes treatment RiceUniversity natBME
, Representative images of capsule formation using the alginate analogs. Scale bar, 2 mm., After initial characterization studies, including purity, solubility, and gel-forming ability, 149 alginate polymers were used for the screening test., Mechanical testing with different alginate formulations. One-way ANOVA with Bonferroni correction was used for statistical analysis;= 0.0009 , ns; non significant for comparisons with SLG20. All error bars denote mean ± s.e.m of n = 20 replicates.
The library preparation involved a multiplex PCR step in amplifying the SNP loci, a barcoding PCR step to add position barcode to each sample, and a ligation-based sequencing adapter amendment procedure., Before optimization, the library on-target rate was 80% regardless of low DNA input overall log-likelihood higher than -200, and 3) goodness measurement higher than 10 where goodness is defined as the difference of log-likelihood between the most likely and the second most likely donor pairs).
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