Stevens-Johnson syndrome (SJS) is a rare and severe kind of erythema multiforme (EM)
By Syed S. A.Reviewed by Sophia Coveney . It is a severe skin reaction that is frequently caused by drugs. SJS frequently starts with a fever and flu-like symptoms.
Stevens-Johnson syndrome is at the milder end of the disease range, whereas toxic epidermal necrolysis is at the more severe end. The HLA-B gene has the highest genetic variants related to SJS. This gene belongs to a group of genes known as the human leukocyte antigen complex. Within a few days, the skin begins to blister and peel, resulting in extremely painful raw regions known as erosions that mimic a severe hot water burn. Skin erosions typically begin on the face and chest before spreading to the rest of the body.
Epidemiology Each year, SJS is predicted to impact two to seven million people. Stevens-Johnson syndrome occurs three times as frequently as toxic epidermal necrolysis. Related StoriesThe patient experienced fever, seropurulent ocular discharge, crusty lips lesions, and de-epithelialization of the oral mucosa the next day. The patient was seen by a doctor after two days, who diagnosed bronchitis and prescribed second-generation cephalosporin.
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